Lost
If you're a fan of the show "Lost" then you're pretty much used to being fed small tidbits of plot that raise more questions than provide answers. This video is the last in a series of viral videos put out by the Lost creators over the past few months. It contains the (~) explanation of what the numbers are (4 8 15 16 23 42) and also what that vaccine is that everybody keeps getting injected in them. In fact, there are probably more real answers in this 6 minute video than there where in the entire 2nd season.